Aim: To evaluate and compare pain perception and time taken for Carie-solve and a conventional technique for caries removal in children. Materials and methods: A total of 20 children with cavitated lesions on both sides in primary teeth of 6–12 years of age were included in the study. In this split-mouth study, randomization was done using the “flip the coin” technique. The total sample size was divided into groups I and II. Airotor was used for group I, whereas Carie-solve was used for another group II. Time taken for both techniques and pain perception were measured and compared using a stopwatch and Wong–Baker Pain Scale. The results were statistically analyzed using the Mann–Whitney U test to compare the two techniques. Results: The mean value of the pain score for the conventional technique was 3.8, and chemomechanical caries removal (CMCR) was 1. On the other hand, the mean time required for caries removal with the CMCR method was 8.87 ± 2.97 seconds and 3.97 ± 0.94 seconds for the conventional method. There was a significant difference in pain perception and time required in both methods of caries removal with a p-value (p = 0.0001). Conclusion: Removal of carious tissue with Carie-solve proved to be efficient, easy to perform, and acceptable for patients; however, the time required for the Carie-solve was much greater than conventional. Clinical significance: An alternative approach for caries removal, which will reduce the child's fear, is required to make future treatments a lot easier as well as instill a positive dental attitude in a child. Carie-solve is one such alternative, which might be helpful in reducing the pain perception of kids associated with the use of high-speed rotary instruments but is also effective in removing the infected dentin.