Citation Information :
Gunti N, Prathigudupu RS, Prasad LK, Chakravarthi P, Chunduru PS, Musunuri RL. Evaluating the Efficacy of Transresveratrol in Extraction Socket of Impacted Mandibular Third Molar: A Double-blind Study. World J Dent 2023; 14 (10):869-876.
Aim: This study aimed to evaluate the effect of transresveratrol on postextraction complications, including pain, swelling, and alveolar bone density.
Materials and methods: A total of 10 extraction sockets were included in this study based on specific criteria. The sockets were randomly divided into two groups—group I received transresveratrol packed in a collagen membrane, while group II received collagen membrane alone. Pain, swelling, and alveolar bone density were assessed. Data entry and analysis were performed using Microsoft (MS) Excel and Statistical Package for the Social Sciences (SPSS) version 22 software. Statistical analysis included mean, standard deviation, proportions, and the independent t-test. A p-value of <0.05 was considered statistically significant.
Results: The mean age of the study population was 25.2 ± 1.64, with 60% males and 40% females. Comparison of pain and swelling between the two groups revealed significant differences on days 1, 3, and 7 (p < 0.05). However, the comparison of alveolar bone density on cone-beam computed tomography (CBCT) systems after 3 months showed differences but was not statistically significant (p = 0.44).
Conclusion: This study concludes that using transresveratrol has a beneficial effect on postextraction swelling, pain, and alveolar bone density.
Clinical significance: The findings of this study suggest that incorporating transresveratrol into the treatment of mandibular third molar extractions may help reduce postoperative complications such as swelling and pain. However, further research is needed to evaluate its impact on alveolar bone density fully.
Yesiltepe S, Kılcı G. Evaluation the relationship between the position and impaction level of the impacted maxillary third molar teeth and marginal bone loss, caries and resorption findings of the second molar teeth with CBCT scans. Oral Radiol 2022;38(2):269–277. DOI: 10.1007/s11282-021-00554-2
Blondeau F, Daniel NG. Extraction of impacted mandibular third molars: postoperative complications and their risk factors. J Can Dent Assoc 2007;73(4):325. PMID: 17484797.
White RP Jr, Shugars DA, Shafer DM, et al. Recovery after third molar surgery: clinical and health-related quality of life outcomes. J Oral Maxillofac Surg 2003;61(5):535–544. DOI: 10.1053/joms.2003.50106
Rood JP, Shehab BA. The radiological prediction of inferior alveolar nerve injury during third molar surgery. Br J Oral Maxillofac Surg 1990;28(1):20–25. DOI: 10.1016/0266-4356(90)90005-6
Kugelberg CF, Ahlström U, Ericson S, et al. Periodontal healing after impacted lower third molar surgery in adolescents and adults. A prospective study. Int J Oral Maxillofac Surg 1991;20(1):18–24. DOI: 10.1016/s0901-5027(05)80689-7
Sifuentes-Cervantes JS, Carrillo-Morales F, Castro-Núñez J, et al. Third molar surgery: past, present, and the future. Oral Surg Oral Med Oral Pathol Oral Radiol 2021;132(5):523–531. DOI: 10.1016/j.oooo.2021.03.004
Farina R, Trombelli L. Wound healing of extraction sockets. Endod Topics 2011;25(1):16–43. DOI: 10.1111/etp.12016
Lyu C, Shao Z, Zou D, et al. Ridge alterations following socket preservation using a collagen membrane in dogs. Biomed Res Int 2020;2020:1487681. DOI: 10.1155/2020/1487681
Muhonen A, Ventä I, Ylipaavalniemi P. Factors predisposing to postoperative complications related to wisdom tooth surgery among university students. J Am Coll Health 1997;46(1):39–42. DOI: 10.1080/07448489709595585
Bhattarai G, Poudel SB, Kook SH, et al. Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis. Acta Biomater 2016;29:398–408. DOI: 10.1016/j.actbio.2015.10.031
Murgia D, Mauceri R, Campisi G, et al. Advance on resveratrol application in bone regeneration: progress and perspectives for use in oral and maxillofacial surgery. Biomolecules 2019;9(3):94. DOI: 10.3390/biom9030094
Dyck GJB, Raj P, Zieroth S, et al. The effects of resveratrol in patients with cardiovascular disease and heart failure: a narrative review. Int J Mol Sci 2019;20(4):904. DOI: 10.3390/ijms20040904
Poulsen MM, Fjeldborg K, Ornstrup MJ, et al. Resveratrol and inflammation: challenges in translating pre-clinical findings to improved patient outcomes. Biochim Biophys Acta 2015;1852(6): 1124–1136. DOI: 10.1016/j.bbadis.2014.12.024
de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 2005;49(5):405–430. DOI: 10.1002/mnfr.200500022
Tamaki N, Cristina Orihuela-Campos R, Inagaki Y, et al. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model. Free Radic Biol Med 2014;75:222–229. DOI: 10.1016/j.freeradbiomed.2014.07.034
Li L, Yu M, Li Y, et al. Synergistic anti-inflammatory and osteogenic n-HA/resveratrol/chitosan composite microspheres for osteoporotic bone regeneration. Bioact Mater 2021;6(5):1255–1266. DOI: 10.1016/j.bioactmat.2020.10.018
Adhikari N, Prasad Aryal Y, Jung JK, et al. Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model. J Periodontal Res 2021;56(4):735–745. DOI: 10.1111/jre.12870
Molez AM, do Nascimento EHL, Haiter Neto F, et al. Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune-enzymatic, and gene expression analysis. J Periodontal Res 2020;55(6):840–849. DOI: 10.1111/jre.12775
Zamai RS, Corrêa MG, Ribeiro FV, et al. Does resveratrol favor peri-implant bone repair in rats with ovariectomy-induced osteoporosis? Gene expression, counter-torque and micro-CT analysis. Braz Oral Res 2023;37:e003. DOI: 10.1590/1807-3107bor-2023.vol37.0003
Corrêa MG, Ribeiro FV, Pimentel SP, et al. Impact of resveratrol in the reduction of the harmful effect of diabetes on peri-implant bone repair: bone-related gene expression, counter-torque and micro-CT analysis in rats. Acta Odontol Scand 2021;79(3):174–181. DOI: 10.1080/00016357.2020.1797159
Movahedian Attar B, Razavi SM, Daneshmand M, et al. Protective effects of resveratrol against osteonecrosis at the extraction site in bisphosphonate-treated rats. Int J Oral Maxillofac Surg 2020;49(11):1518–1522. DOI: 10.1016/j.ijom.2020.02.019
Min KK, Neupane S, Adhikari N, et al. Effects of resveratrol on bone-healing capacity in the mouse tooth extraction socket. J Periodontal Res 2020;55(2):247–257. DOI: 10.1111/jre.12710
Ozcan-Kucuk A, Alan H, Gul M, et al. Evaluating the effect of resveratrol on the healing of extraction sockets in cyclosporine a-treated rats. J Oral Maxillofac Surg 2018;76(7):1404–1413. DOI: 10.1016/j.joms.2018.02.030
Ribeiro FV, Pimentel SP, Corrêa MG, et al. Resveratrol reverses the negative effect of smoking on peri-implant repair in the tibia of rats. Clin Oral Implants Res 2019;30(1):1–10. DOI: 10.1111/clr.13384
Tseng PC, Hou SM, Chen RJ, et al. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. J Bone Miner Res 2011;26(10):2552–2563. DOI: 10.1002/jbmr.460
Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol 2004;287(4):L774–L783. DOI: 10.1152/ajplung.00110.2004
