Citation Information :
Arvina R, Ganapathy D. Effectiveness of Nonsurgical Periodontal Therapy on Salivary Visfatin: A Clinical and Biochemical Analysis. World J Dent 2023; 14 (1):74-78.
Aim: To assess the effectiveness of nonsurgical periodontal therapy (NSPT) on salivary visfatin (VF) levels in chronic periodontitis patients.
Materials and methods: A total of 40 individuals with body mass index (BMI) of 18.5–24.9, aged between 30 and 50 years (group I—n = 20, periodontally healthy and group II1—n = 20, generalized chronic periodontitis patients) were enrolled in this experimental study. Clinical parameters such as periodontal probing depth (PPD) and clinical attachment level (CAL) were recorded. Unstimulated salivary samples were collected and assayed for VF using a human VF enzyme-linked immunosorbent assay (ELISA) kit. After clinical examination and saliva collection at baseline, scaling, and root planing (SRP) was done for generalized chronic periodontitis patients, and after 3 months, clinical examination and saliva collection was done (group II2). The results were analyzed using Statistical Package for Social Sciences (SPSS) software, version 23.0. Within-group comparison between different time frames was made by paired t-test, and intergroup comparison was made by independent t-test. Pearson correlation was done to assess the relationship between variables.
Results: The salivary VF level was higher in group II1 (37.96 ± 1.74 ng/mL) as compared to group I (19.23 ± 1.33 ng/mL). Between groups II1 (before NSPT) and II2 (after NSPT), there was a reduction in PPD from baseline (4.65 ± 0.36) to 3 months (2.73 ± 2.77), and there was a reduction in CAL from baseline (5.04 ± 0.55) to 3 months (2.98 ± 2.22). Also, there was a reduction of VF from baseline (37.96 ± 1.74) to 3 months (19.04 ± 0.34). Pearson correlation in groups II1 and II2 revealed the correlation between VF and clinical parameters (PPD and CAL) was strongly positive and statistically significant.
Conclusion: The present study suggests that there was a significant reduction in salivary VF levels among periodontitis patients after NSPT. Also, there exists a positive correlation between salivary VF and periodontal parameters.
Clinical significance: Salivary VF may be used as a potential diagnostic biomarker in the detection of periodontal diseases. Furthermore, it can be used to monitor the efficacy of the treatment during the course of the management of periodontitis.
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