Aim: This in vitro study was done to evaluate and compare the effect of sectioning and laser welding on the marginal fit and flexural strength of non-hex full-arch screw-retained casted framework. Materials and methods: Five implants were placed parallel to each other in a styrofoam master model. A total number of 20 conventionally casted screw-retained implant-supported frameworks were fabricated, the samples were divided into group I (one-piece nonsectioned and welded) and group II (sectioned and welded). To evaluate the marginal fit, a screw resistance test and one screw test were used. Data were submitted to an unpaired t-test. After evaluating the frameworks for fit, the flexural strength of both types of frameworks was calculated using universal testing machine (UTM). Results: The data was analyzed using an unpaired t-test. On evaluating the frameworks using one screw test, the mean vertical misfit value at the terminal implant for the group I was 293.23 ± 7.82 µm, and for group II was 78.43 ± 1.49 µm, whereas the average misfit values at four implants on applying screw resistance test were 226.70 ± 9.29 (group I) and 71.26 ± 13 (group II), respectively. The average misfit values on two implants using the screw resistance test were 173.14 ± 10.80 and 37.26 ± 2.18 for groups I and II, respectively. The mean value of flexural strength of frameworks after laser welding was 1529.6 MPa, which was statistically nonsignificant when compared to nonsectioned frameworks. Conclusion: Within the limitations of the study, it was concluded that the passivity and vertical fit of the casted one-piece implant framework improved significantly upon sectioning and laser welding. The flexural strength of the laser welded joint was comparable to nonsectioned frameworks. Clinical significance: The laser welding techniques used in this study demonstrated to be able to improve the clinical conditions of a conventionally casted screw-retained prosthesis by lowering the misfit and producing adequate flexural resistance.