Aim: The aim of the present study was to study the effect of different types of implant-supported prosthetic material on the stress distribution in peri-implant bone. And to explore the suitability of recent materials like polyether ether ketone (PEEK) and monolithic zirconia (M4) for implant framework designing. Materials and methods: Virtual mesh was designed for five different prosthetic materials (Mat) namely cobalt-chromium, titanium, zirconia, M4, and PEEK. Forces were directed in vertical, horizontal, and oblique directions to get different fringes of stress severity in the surrounding bone. Finite element analysis (FEA) along with optimization methods was used for in vitro testing and comparison. Statistical analysis was performed using von Mises Stress Analysis and unpaired t-test followed by optimization of FEA results. Results: PEEK was found to have a statistically significant (p-value < 0.0001) result with respect to stress distribution in peri-implant bone in D1 type bone. Moreover, M4 showed favorable results in other bone conditions (D2, D3 type). The responses were optimized through the Signal to Noise Ratio (SNR) concept of Taguchi Technique using MINITAB 17 software technique. Conclusion: Within the limitations of the study PEEK and M4 were found to be the most efficient prosthetic material as compared to the conventionally used metal alloys. Higher crestal bone stresses were reported in all the FEA models suggesting occlusal forces were far more detrimental than the type of prosthetic material used. Clinical significance: The study is an experimental simulation of stresses associated with implant-supported fixed prosthesis material type and its influence on surrounding bone. The findings recommend the significant influence of bone density and type on the choice of prosthetic material and discourage the routine selection of cobalt-chromium for every case.