Aim: The present study was done to assess the accuracy of various cephalometric analyses performed using NemoCeph cephalometric software (digital approach) with manual hand tracing. Materials and methods: This study was carried out by two examiners, 50 lateral cephalograms were selected, 11 angular and eight linear measurements were assessed using both manual and digital methods. Manual tracing is done by placing an acetate tracing sheet on the lateral cephalogram. For digital tracing, the lateral cephalogram is scanned and calibrated with a ruler which was incorporated in the cephalostat at the time of radiographic exposure and traced using NemoCeph software. Results: On intraclass correlation, NemoCeph measurements showed good agreement as hand measurements for majority of the values, suggesting good reliability. Pearson's correlation showed weak correlation with IMPA and AO-BO for examiner 1 and Pog-NB and lower lip-S line for examiner 2. Paired t-test showed significant difference (p < 0.05) for SNB, ANB, occlusal plane, FMA, IMPA, upper lip-S line, lower lip-S line, S-Go, N-Me, and AO-BO for both the examiners. Even though statistically significant differences were found for the majority of the values, all of which lie within two units, except for IMPA and S-Go. Conclusion: Digital cephalometrics has many advantages over manual tracing such as ease of use, instant image acquisition and storage, and time-saving. With further research using cephalometric software and proven clinical performance, digital cephalometric tracings can be preferred over manual methods. Clinical significance: In clinical settings, digital cephalometrics minimizes tracing errors, decreases manual work, and saves a significant amount of time. Moreover, it aids in immediate diagnosis and treatment planning.