Citation Information :
Sudhakar U, Parthiban S, Ebenezer J, Sophia K, Mithradas N, Ravindran N. Collocation of Malondialdehyde and Superoxide Dismutase Levels in Chronic Periodontitis and Pruning them Post-scaling and Root Planing Coupled with Vitamin E Supplementation. World J Dent 2022; 13 (5):503-507.
Aim: The purpose of this study is to determine the effect of vitamin E supplementation on malondialdehyde (MDA) and superoxide dismutase (SOD) status post-scaling and root planing (SRP) in patients with chronic periodontitis.
Materials and methods: A total of 80 randomly selected chronic periodontitis patients were classified into two groups (40 each), group I and group II. Those in group I underwent SRP, whereas those in group II underwent SRP along with orally administered 400 mg of vitamin E every other day for 3 months. Gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded. A baseline examination and a 3-month recall were conducted for all the patients. Serum, saliva, and gingival crevicular fluid (GCF) were collected at baseline and 3 months posttreatment.
Results: The results of the study showed that oxidative stress is more in chronic periodontitis patients. A reduction in CAL and PPD between group I and group II was observed after 3 months. However, it was not statistically significant. Post-periodontal therapy, along with vitamin E supplementation, showed that salivary and GCF MDA levels showed significant reduction at 3 months, whereas serum MDA levels did not. Salivary and serum SOD values showed significant p value after, whereas there was an increase in SOD levels in GCF, which was not statistically significant.
Conclusion: Significant changes in MDA and SOD levels were noted after orally administered vitamin E supplementation. Larger sample sizes along with longitudinal studies were required in different reveries of chronic periodontitis.
Clinical significance: The MDA levels were increased in chronic periodontitis, whereas SOD levels were lowered in chronic periodontitis. Conjugation of vitamin E supplementation improves periodontal healing as well as antioxidant defense.
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