Aim: To evaluate salivary C-reactive protein (CRP) levels in children with skeletal class II malocclusion and with a positive history of sleep disorders. Materials and methods: Twenty-one children aged 8–12 years with skeletal class II malocclusion and at least one sleep disorder participated in the study (group I). Twenty-one age and gender-matched children with no skeletal malocclusion and no reported history of sleep disorders served as a comparison group (group II). All children were evaluated regarding their sleep history and clinically examined to determine craniofacial morphology. Children of group I were subjected to a radiographic assessment including evaluation of airway space. Unstimulated saliva was collected from all children. Salivary CRP was measured using CRP LEIT kit (Agappe) with calibrator, which is a latex-enhanced turbidimetric immunoassay. Statistical analysis for intergroup comparison (two groups) for normally distributed data was done using t-test. Results: There was a significantly higher level of salivary CRP, in children of group I when compared to that of group II children (p < 0.01). Conclusion: Salivary CRP may be a simple and noninvasive tool in the identification and screening of children at high risk for sleep disorders. Clinical significance: Routine salivary CRP monitoring could be a valuable biomarker in early recognition and treatment sleep disorders in children.