Aim: The aim of this study is to compare the shear bond strength and diametrical tensile strength of resin luting cement after the incorporation of titanium dioxide nanoparticles (TDNP) and hydroxyapatite nanoparticles (HANP). Materials and methods: Three main sample groups and three subgroups in the two experimental groups were made based on the weight percentage of nanoparticles. Forty-two samples were prepared by injecting the cement into a polytetrafluoroethylene (PTFE) mold positioned onto the occlusal surface of human maxillary second premolars embedded in acrylic blocks (prepared for bonding). Light curing was carried out following the manufacturer's instructions. The prepared samples were loaded at a crosshead speed of 1 mm/min on a universal-testing machine. The shear bond strength was evaluated by measuring the force (N) at which the bonding failed. Forty-two cylindrical samples were fabricated by injecting the cement into PTFE molds. The prepared samples were mounted on a universal-testing machine diametrically at a crosshead speed of 1 mm/min, and diametrical tensile strength was calculated by measuring the maximum force (N) at which the failure occurred. Results: Statistical analysis was carried out using one-way analysis of variance (ANOVA) and Tukey's honest significant difference tests. Maximum shear bond strength and diametrical tensile strength were achieved after 2 wt% of TDNP was incorporated into the resin luting cement (VARIOLINK N). Conclusion: TDNP can be considered a promising nanofiller for the manufacture of dental resin luting cement. Clinical significance: An ideal luting cement should have adequate bond strength and tensile strength properties to provide a durable bond for any indirect restorations. This study evaluates the shear bond strength and diametrical tensile strength after incorporating TiO₂ and HANP into Variolink (Resin Luting Cement), which can be an eye-opener for manufacturing resin luting cement with potential nanoparticles as fillers.