The Potential of Snail (Achatina Fulica) Mucus Gel as a Phythopharmaca to Accelerate the Inflammation Process during Wound Healing
Yosaphat B Rosanto, Cahya Y Hasan, Rahardjo, Antonius Surya
Citation Information :
Rosanto YB, Hasan CY, R, Surya A. The Potential of Snail (Achatina Fulica) Mucus Gel as a Phythopharmaca to Accelerate the Inflammation Process during Wound Healing. World J Dent 2022; 13 (3):224-227.
Aim: To determine the potential of snail (Achatina fulica) mucus gel as a phytopharmaca material to accelerate the inflammatory process during wound healing
Materials and methods: Snail mucus gel was mixed with 3% CMC-Na to concentrations of 0% (control), 24%, 48%, and 96% snail mucus. Four 5-mm diameter punch biopsy excision wounds were made on the back skin of Wistar rats (n = 6). The snail mucus gel was applied to the back wounds of the mice. The mice were euthanized on days 2, 4, and 7 and hematoxylin and eosin-stained sections of the skin wound area were prepared. The number of polymorphonuclear leukocytes in the dermis was observed during wound healing using a binocular microscope (400x).
Results: A significant difference in the number of polymorphonuclear leukocytes (p = 0.000) was observed. The increase in the number of polymorphonuclear leukocytes peaked on day 4 in response to the 48% and 96% snail mucus gel concentrations. The 96% snail mucus gel had significantly more polymorphonuclear leukocytes than those in the other concentrations according to Tukey's test.
Conclusion: Snail mucus accelerated the inflammatory process during wound healing.
Clinical significance: Snail mucus is a potential material to be developed into a drug to accelerate wound healing. The toxicity, biocompatibility, and stability of the 96% snail mucus gel must be tested to produce a useful phytopharmaca product.
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