World Journal of Dentistry

Register      Login

VOLUME 13 , ISSUE 1 ( January-February, 2022 ) > List of Articles


Use of Topical Ozone Therapy for Wound Healing after Transalveolar Extractions: A Miracle Alternative Therapy

Devyani Bahl, Soumi Samuel, R Narayana Charyulu, Sudhir Dole

Keywords : Ozone therapy, Pain, Randomised control trial, Transalveolar extraction, Wound healing

Citation Information : Bahl D, Samuel S, Charyulu RN, Dole S. Use of Topical Ozone Therapy for Wound Healing after Transalveolar Extractions: A Miracle Alternative Therapy. World J Dent 2022; 13 (1):57-61.

DOI: 10.5005/jp-journals-10015-1888

License: CC BY-NC 4.0

Published Online: 29-12-2021

Copyright Statement:  Copyright © 2022; The Author(s).


Aim: To evaluate the effect of topical ozone therapy for wound healing after transalveolar extractions. Materials and methods: A prospective study was conducted on 72 patients who underwent transalveolar extraction procedure and were divided into 2 groups–Ozone group and the control group with 36 patients in each group. After the procedure, the patients in the ozone group, received ozonated oil and the control group received normal saline irrigation. The ozone group patients were prescribed to apply the Ozonated oil locally at the extraction site for 3 times daily for a period of 5 days. Antibiotics were not prescribed in the ozone group but were given for the control group. Analgesics were given on SOS basis in the ozone group and for 5 days in the control group. The subjects were evaluated for postoperative wound healing, pain and swelling on the 3rd and 7th day. The final POSSE score and the number of analgesics taken were recorded on the 7th day. Results: Patients in the ozone group had better wound healing on POD3 and POD7 when compared to the control group. There were decreased VAS pain, and swelling scores in the ozone group compared to the control group with statistically significant difference (p < 0.001). The patients in the ozone group took lesser analgesics than the control group. Overall post-extraction discomfort was significantly lesser in the ozone group when compared to the control group (p < 0.001). Conclusion: With the present study results, we can say that the topical ozone therapy can be used as an effective treatment modality for accelerating healing and reducing the pain after transalveolar dental extractions. Clinical significance: Dental extraction, though routinely done procedure in the clinical setting, has various postoperative complications, pain and swelling being the most common. Hence, ozone therapy can be used as an effective topical agent to manage post-extraction pain and swelling in healthy patients without the need for excess medications.

  1. Bocci V. Ozone as Janus: this controversial gas can be either toxic or medically useful. Mediators Inflamm 2004;13(1):3–11. DOI: 10.1080/0962935062000197083
  2. Travagli V, Zanardi I, Valacchi G, et al. Ozone and ozonated oils in skin diseases: a review. Mediators Inflamm 2010;2010:610418. DOI: 10.1155/2010/610418
  3. Seidler V, Linetskiy I, Hubálková H, et al. Ozone and its usage in general medicine and dentistry. A review article. Prague Med Rep 2008;109(1):5–13.
  4. Elvis AM, Ekta JS. Ozone therapy: a clinical review. J Nat Sci Biol Med 2011;2(1):66–70. DOI: 10.4103/0976-9668.82319
  5. Clavo B, Catalá L, Pérez JL, et al. Ozone therapy on cerebral blood flow: a preliminary report. Evid Based Complement Alternat Med 2004;1(3):315–319. DOI: 10.1093/ecam/neh039
  6. Bayson A, Lynch E. Antimicrobial effects of ozone on caries. In: Lynch E, (ed.) Ozone: The Revolution in Dentistry. London: Quintessence Publishing Co. 2004. pp. 165–172.
  7. Iliadis D, Millar BJ. Ozone and its use in periodontal treatment. Open J Stomatol 2013;3(2):197–202. DOI: 10.4236/ojst.2013.32034
  8. Mandhare MN, Jagdale DM, Gaikwad PL, et al. Miracle of ozone therapy as an alternative medicine. Int J Pharm Chem Biol Sci 2012;2(1):63–71.
  9. Ahmedi J, Ahmedi E, Sejfija O, et al. Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction. Eur J Dent 2016;10: 381–385. DOI: 10.4103/1305-7456.184168
  10. Kazancioglu HO, Kurklu E, Ezirganli S. Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. Int J Oral Maxillofac Surg 2014;43:644. DOI: 10.1016/j.ijom.2013.11.006
  11. Uysal B. Ozonated olive oils and the troubles. J Intercult Ethnopharmacol 2014;3(2):49-50. DOI: 10.5455/jice.20140314090801
  12. Reddy SA, Reddy N, Dinapadu S, et al. Role of ozone therapy in minimal intervention dentistry and endodontics – a review. J Int Oral Health 2013;5:102.
  13. Mohammadi Z, Shalavi S, Soltani MK, et al. A review of the properties and applications of ozone in endodontics: an update. Iran Endod J 2013;8:40.
  14. Broadwater WT, Hoehn RC. Sensitivity of three selected bacterial species to ozone. Appl Microbiol 1973;26(3):391–393. DOI: 10.1128/am.26.3.391-393.1973
  15. Bocci V. Autohaemotherapy after treatment of blood with ozone. A reappraisal. J Int Med Res 1994;22(3):131–144. DOI: 10.1177/030006059402200301
  16. Sivalingam VP, Panneerselvam E, Raja KV, et al. Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? A randomized controlled trial. J Oral Maxillofac Surg 2017;75(1):51e1–51e9. DOI: 10.1016/j.joms.2016.09.014.
  17. Naik SV, Rajeshwari K, Kohli S, et al. Ozone – a biological therapy in dentistry reality or myth? Open Dent J 2016;10:196–206. DOI: 10.2174/1874210601610010196
  18. Werkmeister H. Subatmospheric O2/O3 treatment of therapy-resistant wounds and ulcerations. OzoNachrichten 1985;4:53–59. DOI: 10.1586/17434440.3.2.175
  19. Azuma K, Mori T, Kawamoto K, et al. Anti-inflammatory effects of ozonated water in an experimental mouse model. Biomed Rep 2014;2:671. DOI: 10.3892/br.2014.290
  20. Xiao W, Tang H, Wu M, et al. Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway. Biosci Rep 2017;37(6):BSR20170658. DOI: 10.1042/BSR20170658
  21. Sujatha B, Manoj Kumar MG, Pratap Gowd MJ, et al. Ozone therapy – a paradigm shift in dentistry. An Open Access Peer Reviewed E. J Health Sci 2013;2(3):1–10.
  22. Bacchi S, Palumbo P, Sponta A, et al. Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review. Antiinflamm Antiallergy Agents Med Chem 2012;11(1):52–64. DOI: 10.2174/187152312803476255
  23. Slade GD, Foy SP, Shugars DA, et al. The impact of third molar symptoms, pain, and swelling on oral health-related quality of life. J Oral Maxillofac Surg 2004;62(9):1118–1124. DOI: 10.1016/j.joms.2003.11.014
  24. Sukegawa S, Yokota K, Kanno T, et al. What are the risk factors for postoperative infections of third molar extraction surgery: a retrospective clinical study? Med Oral Patol Oral Cir Bucal 2019;24(1):e123–e129. DOI: 10.4317/medoral.22556
  25. Lynch E. Evidence-based caries reversal using ozone. J Esthet Restor Dent 2008;20(4):218–222. DOI: 10.1111/j.1708-8240.2008.00183
  26. Goyal M, Marya K, Jhamb A, et al. Comparative evaluation of surgical outcome after removal of impacted mandibular third molars using a Piezotome or a conventional handpiece: a prospective study. Br J Oral Maxillofac Surg 2012;50:556–561. DOI: 10.1016/j.bjoms.2011.10.010
  27. Borle RM. Textbook of Oral and Maxillofacial Surgery. JP Medical Ltd. 2014.
  28. Viebahn Haensler R. The Use of Ozone in Medicine. Heidelberg: Karl F, Haug Publishers 2002.
  29. Kim K, Brar P, Jakubowski J, et al. The use of corticosteroids and nonsteroidal anti-inflammatory medication for the management of pain and inflammation after third molar surgery: a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:630. DOI: 10.1016/j.tripleo.2008.11.005
  30. Markovic AB, Todorovic L. Post-operative analgesia after third molar surgery: contribution of the use of long-acting local anaesthetics, low-power laser, and diclofenac. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:4–8. DOI: 10.1016/j.tripleo.2006.02.024
  31. Lago ML, Dinitz FM, Serna RC, et al. Relationships between surgical difficulty and post-operative pain in lower third molar extractions. J Oral Maxillofac Surg 2007;65:979–983. DOI: 10.1016/j.joms.2006.06.281
  32. Markovic A, Todorovic L. Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: a clinical trial. Int J Oral Maxillofac Surg 2007; 36:226–229. DOI: 10.1016/j.ijom.2006.10.006
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.