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VOLUME 12 , ISSUE 6 ( November-December, 2021 ) > List of Articles


Evaluation of Ofloxacin and Ornidazole as an Adjunct to Scaling and Root Planing in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Study

Athira K Chermmal, MB Harsha, Marenahalli R Vivekananda

Keywords : Chronic periodontitis, Ofloxacin, Ornidazole, Root planing, Scaling

Citation Information : Chermmal AK, Harsha M, Vivekananda MR. Evaluation of Ofloxacin and Ornidazole as an Adjunct to Scaling and Root Planing in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Study. World J Dent 2021; 12 (6):485-491.

DOI: 10.5005/jp-journals-10015-1881

License: CC BY-NC 4.0

Published Online: 24-11-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Aim and objective: Over the years, treatment for chronic periodontitis is changing owing to an improved understanding of the pathogenesis of the periodontal disease. Tissue invasive properties of periodontal pathogens have necessitated the use of antimicrobial agents as an adjunct to mechanical plaque control in the treatment of periodontitis. Hence, the study aimed to evaluate the efficacy of ofloxacin–ornidazole combination therapy as an adjunct to scaling and root planing in the treatment of generalized chronic periodontitis. Materials and methods: A total of 40 study participants, aged from 25 to 55 years, with generalized chronic periodontitis were selected. They were randomly divided into two groups—Group I: receiving scaling and root planing along with ofloxacin–ornidazole combination therapy and group II: receiving scaling and root planing. Gingival index (GI), sulcular bleeding index (SBI), and probing pocket depth (PPD) scores were recorded at baseline, 14th day, and after 1 month. Results: Both the groups showed a reduction in GI scores, SBI scores, and mean pocket probing depth from baseline to 14th day and 1 month. However, the improvement in scores was better in a group with the ofloxacin–ornidazole combination, than the group with scaling and root planing alone. The intergroup comparison of the gingival indices, SBI, and mean pocket probing depth at baseline, 14th day, and 1 month have shown the statistically significant difference. Conclusion: It can be concluded that ofloxacin–ornidazole combination therapy is well tolerated by the patients, safe, favorable patient compliance, and proved to be effective in patients with generalized chronic periodontitis when used as an adjunct to mechanical plaque control. Clinical significance: Ofloxacin–ornidazole combination can be used as an adjuvant in the treatment of generalized chronic periodontitis.

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