Aim and objective: The aim of this case report is on an interdisciplinary orthodontic and surgical treatment approach of facial asymmetry due to congenital hemifacial microsomia (HFM). Background: Hemifacial microsomia is the second common congenital craniofacial deformity after cleft lip and palate, which presents with different clinical characteristics, including an extremely variable asymmetrical presentation. And there is no standardized treatment protocol for this type of asymmetry hence individualized treatment plan for every patient can result in the best esthetic and functional stability. Case description: This case study emphasizes on an adult patient who has congenital HFM with class I skeletal malocclusion involving asymmetry from the supraorbital level to the lower border of the face. Pre-surgical orthodontics is done initially by aligning the teeth and placing asymmetrical bite block, followed by LeFort I osteotomy with differential impaction (transverse) and bilateral sagittal split osteotomy with rotation along with advancement genioplasty, and finally, post-orthodontic settling done. Conclusion: A team effort of surgical orthodontists and surgeons with the aid of advanced imaging and software technology made us make an amazing change in patient's life both esthetically and functionally. Clinical significance: This new innovative method is both a time-saving and conservative method both for patients and dentists.