Aim: Squamous cell carcinoma (OSCC) is the most common malignancy occurring in the oral cavity. It causes local invasion and nodal metastasis leading to an increase in morbidity rate. Vascular endothelial growth factor (VEGF)-C has been the most widely studied molecule involved in lymphangiogenesis. The aim is to study the expression of VEGF-C in OSCC using the immunohistochemical (IHC) method and is correlated with nodal metastasis. Materials and methods: The study group consisted of 49 clinically and histopathologically diagnosed cases of OSCC. The tissue sections were subjected to IHC staining with anti-VEGF-C antibody and assessed for its expression and are correlated with the lymph node metastasis. Results: Out of 49 cases, 26 cases showed lymph node metastasis. On Chi-square analysis, the expression of VEGF-C was statistically significant with lymph node metastasis (p < 0.05). But, the expression of VEGF-C with clinicopathological staging and grading was not significant. Conclusion: The present study results suggest VEGF-C can be used as an indicator marker in lymph node metastasis. Clinical significance: Vascular endothelial growth factor-C marker can be recommended for the prediction of lymph node metastasis in oral squamous cell carcinoma.
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