Aim: The study was aimed to examine the effectiveness level of minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of the star fruit leaf extract on the growth of Streptococcus sanguinis (S. sanguinis) bacteria at concentration 60, 40, 20, 10, and 5%. Materials and methods: This study was laboratory experimental research with the posttest-only control group design. The effectiveness test of the star fruit leaf extract on the growth of S. sanguinis was performed with dilution method. The leaf extract of star fruit was made by the maceration technique from each concentration, suspension of S. sanguinis bacteria was added, repetition done four times, and then observation was conducted. The data analysis used was the one-way ANOVA test. Results: The result showed that MIC concentration of the extract on the growth of S. sanguinis was 5% and MBC concentration was 10%. Conclusion: The star fruit leaf extract has antimicrobial efficacy against S. sanguinis. Clinical significance: The star fruit leaf extract has the potential capacity to prevent and cure dental caries, recurrent aphthous stomatitis (RAS), and periodontal disease.
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