World Journal of Dentistry

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VOLUME 11 , ISSUE 1 ( January-February, 2020 ) > List of Articles

ORIGINAL RESEARCH

Antifungal Activity of Aloe Vera Leaf and Gel Extracts Against Candida albicans: An In Vitro Study

M Shilpa, Vinaya Bhat, A Veena Shetty, Mora SR Reddy, Prashant Punde

Keywords : Aloe vera, Antifungal, Candida albicans, Natural

Citation Information : Shilpa M, Bhat V, Shetty AV, Reddy MS, Punde P. Antifungal Activity of Aloe Vera Leaf and Gel Extracts Against Candida albicans: An In Vitro Study. World J Dent 2020; 11 (1):36-40.

DOI: 10.5005/jp-journals-10015-1701

License: CC BY-NC 4.0

Published Online: 01-02-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Abstract

Aim: The present study was conducted with an aim to assess the antimicrobial activity of ethanolic extracts of aloe vera leaf and gel against Candida albicans in vitro. Materials and methods: Fresh leaves were collected from the aloe vera plants naturally grown in Coorg. Aloe vera leaf as well as gel was separated, extracted with 95% ethanol in rotary shaker at constant temperature for 3 days, evaporated in a heating mantle, and stored in screw cap test tubes at 4°C for further analysis. Antifungal activity of aloe vera leaf and gel extracts against C. albicans was assessed by well diffusion method. Further, gel extracts of aloe vera at different dilutions (500, 400, 300, and 200 μL) were prepared and the turbidity was analyzed. Results: Results showed that the ethanolic extract of aloe vera leaf did not show antifungal activity against C. albicans. A maximum of 99.33% antifungal activity was shown by 400 μL of aloe vera gel extract. The minimum inhibitory concentration of aloe vera gel extract was 200 μL (98.2% inhibition). Conclusion: The ethanolic extract of aloe vera gel showed considerable antifungal activity against C. albicans. Clinical significance: Modalities targeted on the use of aloe vera against C. albicans can prove to be more beneficial and consistent compared to conventional antifungals for preventive and/or therapeutic purposes against a variety of oral fungal diseases.


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