Resolving the Diagnostic Dilemma of Clear Cell Odontogenic Carcinoma Using Special Stains: A Case Report
A Lavanya, SV Sowmya, Rajanikanth B Rajaram, Anand Devaraj, Vanishri C Haragannavar
Clear cell odontogenic carcinoma, Mandibular neoplasm, Special stains
Citation Information :
Lavanya A, Sowmya S, Rajaram RB, Devaraj A, Haragannavar VC. Resolving the Diagnostic Dilemma of Clear Cell Odontogenic Carcinoma Using Special Stains: A Case Report. World J Dent 2019; 10 (4):316-320.
Aim: To resolve the diagnostic dilemma of clear cell odontogenic carcinoma (CCOCa) using various special stains.
Background: Clear cell odontogenic carcinoma is a rare malignant odontogenic tumor with a female predilection, occurring predominantly in the mandible. It is an aggressive tumor with frequent recurrences (55%) and high metastatic potential (31%).
Case description: Herein, we report a case of an unusual extensive mandibular tumor mass in 49-year-old male patient who posed diagnostic challenges due to similar microscopic features of oral squamous cell carcinoma (OSCC), clear cell mucoepidermoid carcinoma (CCMEC), hyalinizing clear cell carcinoma (CCC), epithelial myoepithelial carcinoma (EMC), clear cell variant of calcifying epithelial odontogenic tumor (CCCEOT), and clear cell odontogenic ghost cell tumor (CCOGCT).
Conclusion: The use of appropriate special stains like mucicarmine, Van Gieson, and Periodic Acid Schiff with and without diastase paved the way toward confirmatory diagnosis.
Clinical significance: Good knowledge and right practice of various special staining techniques in histopathology provides a rapid and reproducible result with better diagnosis.
Nazir H, Salroo IN, Mahadesh J, et al. Clear cell entities of the head and neck: A histopathological review. IOSR J Dent Med Sci 2015;14(6): 125–135.
Siraj F, Kaur M, Agrawal U. Clear cell odontogenic carcinoma of maxilla: A diagnostic challenge. Clin Cancer Invest J 2016 May 1;5(3):256–258.
Premalatha BR, Rao RS, Patil S, et al. Clear cell tumors of the head and neck: an overview. World J Dent 2012 Oct;3(4):344–349. DOI: 10.5005/jp-journals-10015-1187.
Elbeshir EI, Harris M, Barrett AW. Clear cell odontogenic carcinoma of the maxilla: clinical, histological and immunohistochemical features of a case. Oral Oncol 2004 Sep 1;40(8–9):91–94. DOI: 10.1016/j.ooe.2004.05.004.
Jayapalan CS, George A, Noufal A, et al. Clear Cell Odontogenic Carcinoma (CCOC): Mini-Review of Literature and Case Report of Mandibular Radiolucency in 17-year Girl. Diagn Pathol Open 2016;1(2):120.
Kwon IJ, Kim SM, Amponsah EK, et al. Mandibular clear cell odontogenic carcinoma. World J Surg Oncol 2015 Dec;13(1):284. DOI: 10.1186/s12957-015-0693-4.
Datar UV, Kamat MS, Kanitkar SS, et al. Clear cell odontogenic carcinoma: A rare case report with emphasis on differential diagnosis. J Cancer Res Ther 2017 Apr 1;13(2):374–377. DOI: 10.4103/0973-1482.187381.
Swain N, Dhariwal R, Ray JG. Clear cell odontogenic carcinoma of maxilla: A case report and mini review. J Oral Maxillofac Pathol 2013;17(1):89–94. DOI: 10.4103/0973-029X.110681.
Krishnamurthy A, Ramshankar V, Majhi U. Clear cell odontogenic carcinoma of the mandible and temporomandibuar joint with cervical lymph nodal metastasis. Natl J Maxillofac Surg 2014 Jul;5(2):221–223. DOI: 10.4103/0975-5950.154842.
Kumamoto H, Yamazaki S, Sato A, et al. Clear cell odontogenic tumor in the mandible: report of a case with duct-like appearances and dentinoid induction. J Oral Pathol Med 2000 Jan;29(1):43–47. DOI: 10.1034/j.1600-0714.2000.290108.x.
Avninder S, Rakheja D, Bhatnagar A. Clear cell odontogenic carcinoma: a diagnostic and therapeutic dilemma. World J Surg Oncol 2006 Dec;4(1):91. DOI: 10.1186/1477-7819-4-91.
Varma S, Shameena PM, Sudha S, et al. Clear cell variant of intraosseous mucoepidermoid carcinoma: report of a rare entity. J Oral Maxillofac Pathol 2012 Jan;16(1):141–144. DOI: 10.4103/0973-029X.92994.
Turatti E, Brasil J. Clear cell variant of calcifying epithelial odontogenic tumor: Case report with immunohistochemical findings. J Clin Exp Dent 2015 Feb;7(1):e163–e166. DOI: 10.4317/jced.51995.
Chatterjee RP, Gayen S, Kundu S, et al. A unique case of clear cell variant of calcifying epithelial odontogenic tumor involving the maxilla. Dent Res J 2017 Jul;14(4):293–296. DOI: 10.4103/1735-3327.211623.
Yoon JH, Ahn SG, Kim SG, et al. Odontogenic ghost cell tumour with clear cell components: clear cell odontogenic ghost cell tumour? J Oral Pathol Med 2004 Jul;33(6):376–379. DOI: 10.1111/j.1600-0714.2004.00200.x.