World Journal of Dentistry

Register      Login

VOLUME 10 , ISSUE 1 ( January-February, 2019 ) > List of Articles


Eosinophilic Toto Bodies

Wafa Khan, Shwetha Nambiar K

Keywords : Eosinophilic bodies, Inflammation, Toto bodies

Citation Information : Khan W, K SN. Eosinophilic Toto Bodies. World J Dent 2019; 10 (1):78-82.

DOI: 10.5005/jp-journals-10015-1607

License: CC BY-NC 4.0

Published Online: 01-02-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Aim: This review aims to discuss the structure, origin of toto bodies and demonstrate the possible theories responsible for its formation. Background: The eosinophilic Toto bodies are characterized by homogeneous or irregular masses varying in size and number. These unusual bodies are found in the top most layers of oral epithelium and derive its name “mucopolysaccharide keratin dystrophy” based on the nature of its composition. The incidence and severity of toto bodies have been correlated with the amount of the inflammatory response present in the connective tissue. These bodies have various theories of origin like fibrin, keratin, mucins, and glycoproteins. Review results: To demonstrate the nature of these eosinophilic bodies; two cases-pyogenic granuloma and oral squamous cell carcinoma were studied using special stains. It was observed that Toto bodies were positive for periodic acid-Schiff (PAS), modified Papanicolaou (Pap), Masson's trichrome and combined PAS-PAP staining techniques. However, staining with Alcian blue, Congo red, mucicarmine and toluidine blue were negative for Toto bodies. Conclusion: It may be concluded that Toto bodies can be best identified using Masson's trichrome stain followed by combined PAS-PAP, PAS, and PAP which characterizes them mainly as glycoproteins and keratins. Clinical significance: The presence of Toto bodies is indicative of inflammatory reaction, and their differential staining in the positive stains depends on the nature and severity of inflammation present in a lesion.

PDF Share
  1. Sah K. Toto bodies. J Oral Maxillofac Pathol 2016;20:9-10.
  2. Archard HO, Denys FR, Martinez MG. Electron microscopic observations of “keratin pools” in chronic hyperplastic oral mucosa. Journal of Oral Pathology & Medicine. 1976; 5(6):371-384.
  3. Chen SY. Ultrastructure of eosinophilic bodies in the degenerative surface epithelium of chronic hyperplastic oral lesions. Oral Surgery, Oral Medicine, Oral Pathology. 1977;43(2):256-266.
  4. Kulkarni M, Agrawal T, Dhas V. Histopathologic bodies: An insight. Journal of the International Clinical Dental Research Organization. 2011;3(1):43-47.
  5. Buchner A, Mlinek A, Calderon S. Eosinophilic bodies in the epithelium of oral inflammatory hyperplastic lesions: Histopatholgic and histochemical study. Oral Surgery, Oral Medicine, Oral Pathology. 1976;41(3):378-384.
  6. Suvarna KS, Layton C, Bancroft JD, editors. Bancroft's Theory and Practice of Histological Techniques E-Book. Elsevier Health Sciences; 2018 Feb 27.
  7. Rao RS, Patil S, Majumdar B, Oswal RG. Comparison of special stains for keratin with routine hematoxylin and eosin stain. Journal of international oral health: JIOH. 2015;7(3):1-5.
  8. Caliaperoumal SK, Srinivasan S, Munshi MA. Comparison and Demonstration of Surface Keratin Staining Quality by Modified Papanicalou Stain, Modified Mallory's Stain and Hematoxylin and Eosin Stain in Verrucous Carcinoma and Normal Keratinizing Epithelium. Int. J. Curr. Microbiol. App. Sci. 2017;6 (2):1287-1293.
  9. Johnson PL, Klein MN. Application of the Papanicolaou stains to paraffin sections. Stain technology. 1956; 31(5): 223-225.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.