Aim: The present study aimed at correlating the flow rate of the stimulated and unstimulated saliva in chronic periodontitis.
Materials and methods: This study composed of 100 subjects between the age group of 25 years and 45 years. These subjects are categorized into four groups, placing 25 subjects in each. Group 1 with 25 healthy patients (no loss of attachment clinically), group 2 with 25 mild chronic periodontitis subjects (1-2 mm of attachment level clinically), group 3 with 25 moderate chronic periodontitis subjects (3-4 mm of attachment level clinically), group 4 with 25 severe chronic periodontitis subjects (5 mm of attachment level clinically), split method was used to collect the stimulated and unstimulated saliva. A calibrated digital balance was used to weigh the bottle before and after the collection of saliva. The result was considered to be statistically significant at a p value less than 0.05 (p <0.05).
Result: The stimulated and unstimulated flow rate of saliva was high in group 1 subjects (0.920 ± 0.240, 1.366 ± 0.280) followed by group 2 subjects (0.780 ± 0.246, 0.920 ± 0.146), group 3 subjects (0.408 ± 0.132, 0.590 ± 0.110), and group 4 subjects (0.221 ± 0.348, 0.301 ± 0.216). There was a significant difference in the salivary flow rate between the groups statistically with p value 0.0001.
Conclusion: The stimulated and unstimulated salivary flow rate decreased with the severity of the progression of the chronic periodontitis.
Clinical significance: The importance of saliva on oral function includes antimicrobial activity, buffering function of pH, cleansing action, mastication, and swallowing. Therefore, a decrease in the ability to produce saliva leads to various oral infections.
Loe H. Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care 1993;16:329-334.
Nunn M. Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontology 2000, 2003;32:11-23.
Zulkarnain S, Azirrawani A. Association between Salivary Parameters and Periodontal Disease. International Medical Journal 2013;20(5):1-5.
Dodds MW, Johnson DA, Yeh CK. Health benefits of saliva: a review. J Dent 2005;33: 223-233.
Shimazaki Y et al. Stimulated salivary flow rate and oral health status. Journal of Oral Science 2016:1-7.
Foglio-Bonda PL, Migliario M, Rocchetti V, Pattarino F, Foglio- Bonda A. Daily and annually variation of unstimulated whole saliva flow rate and pH and their relation with body profile in healthy young adults. Eur. Rev. Med. Pharmacol. Sci. 2013; 17(18):2538-2545.
Yamamoto K, Kurihara M, Matsusue Y, Imanishi M, Tsuyuki M, Kirita T. Whole saliva flow rate and body profile in healthy young adults. Arch. Oral Biol. 2009; 54(5):464-469.
Donna L, Anne D, Haffajee, Socransky S. Effects of periodontitis and smoking on the microbiota of oral mucous membranes and saliva in systemically healthy subjects. J Clin Periodontol 2003; 30(12):1031.
Larmas M. Saliva and dental caries: diagnostic tests for normal dental practice. Int Dent J 1992;42(4):199-208.
Abiodun O. Arigbede, B. Osagbemiro Babatope, and M. Kolude Bamidele Periodontitis and systemic diseases: A literature review. J Indian Soc Periodontol. 2012 Oct-Dec; 16(4): 487-491.
Farsi N, Al Amoudi N, Farsi J, Bokhary S, Sonbul H. Periodontal health and its relationship with salivary factors among different age groups in a Saudi population. Oral Health Prev Dent 2008;6:147-154.
Marton K, Madlena M, Banoczy J, et al. Unstimulated whole saliva flow rate in relation to sicca symptoms in Hungary. Oral Dis 2008;14:472-477.
Almstahl A, Wikstrom M. Oral microflora in subjects with reduced salivary secretion. J Dent Res 1999;78(8):1410-1416.
Hirotomi T, Yoshihara A, Ogawa H, Ito K, Igarashi A, Miyazaki H. Salivary spinability and periodontal disease progression in an elderly population. Arch Oral Biol, 2008;53: 1071-1076.
Shaila M, Pai GP, Shetty P. Salivary protein concentration, flow rate, buffer capacity and pH estimation: A comparative study among young and elderly subjects, both normal and with gingivitis and periodontitis. Journal of Indian Society of Periodontology 2013;17(1):42-46.
Loesche WJ, Schork A, Terpenning MS, Chen YM, Stoll J. Factors which influence levels of selected organisms in saliva of older individuals. J Clin Microbiol. 1995 Oct;33(10): 2550-2557.
Bhattarai KR, Junjappa R, Handigund M, Kim HR, Chae HJ. The imprint of salivarysecretion in autoimmunedisorders and related pathological conditions. Autoimmun Rev. 2018 Apr;17(4):376-390.
Yoshitaka Yamauchi, Tomonori Matsuno, Kazuhiko Omata, and Tazuko Satoh..Relationship between hyposalivation and oxidative stress in aging mice. J Clin Biochem Nutr. 2017 Jul; 61(1): 40-46.
Hamada T NT, Kimura T, Arisawa K, Yoneda K, Yamamoto T, Osaki T. Treatment of xerostomia with the bile secretionstimulant drug anethole trithione: A clinical trial. Am J Med Sci 1999;318:6.
McDonald E, Marino C. Dry mouth: diagnosing and treating its multiple causes. Geriatrics. 1991 Mar;46(3):61-63.