World Journal of Dentistry

Register      Login

VOLUME 1 , ISSUE 1 ( April-June, 2010 ) > List of Articles


Spindle Cell Carcinoma of the Oral Cavity: A Case Report of a Rare Entity and Review of Literature

Nilima Prakash, MS Harish Kumar, P Sharada, GL Pradeep

Citation Information : Prakash N, Harish Kumar M, Sharada P, Pradeep G. Spindle Cell Carcinoma of the Oral Cavity: A Case Report of a Rare Entity and Review of Literature. World J Dent 2010; 1 (1):55-58.

DOI: 10.5005/jp-journals-10015-1011

Published Online: 01-12-2011

Copyright Statement:  Copyright © 2010; The Author(s).


Spindle cell carcinoma is a rare and peculiar biphasic malignant neoplasm that occurs mainly in the upper aerodigestive tract. It consists of sarcomatoid proliferation of pleomorphic spindle cells and squamous cell carcinoma. It is considered potentially aggressive in its biological nature with a high incidence of metastases. We report a case of this tumor with an unusual clinical course. The histogenesis of the spindle cell component is discussed in detail in the review of literature.

PDF Share
  1. Spindle cell carcinoma of the larynx. Review of 26 cases including DNA content and immunohistochemistry. Human Pathology 1997;28(6):664-73.
  2. A case of spindle cell carcinoma of the oral cavity: With special reference to cytopathological features and review of literature. Oral Med Pathol 2006;11:127-38.
  3. Spindle cell carcinoma of the oral cavity and oropharynx: Factors affecting outcome. J Chin Med Assoc 2006;69(10):478-83.
  4. Spindle cell carcinoma of the gingiva: Report of an autopsy case. J Oral Pathol Med 1998;27:180-84.
  5. Spindle cell carcinoma of the oral cavity. A clinicopathologic assessment of fifty-nine cases. Oral Surg Oral Med Oral Path 1980;50(6):523-34.
  6. Oral spindle cell neoplasms: A review of 307 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:717-24.
  7. Doðan, Ayþe Sertçelik, Yaþar Ayva. A rare variant of squamous cell carcinoma of the tongue; spindle cell carcinoma. Ankara Üniversitesi Týp Fakültesi Mecmuasý 2005;58:11-14.
  8. Immunohistochemical p53 expression patterns in sarcomatoid carcinomas of the upper respiratory tract. Am J Surg Pathol 2002;26:1024-31.
  9. Spindle cell (sarcomatoid) carcinoma of the larynx. A clinicopathologic study of 187 cases. Am J Surg Pathol 2002;26:153-70.
  10. Spindle-cell carcinoma of the upper aerodigestive tract mucosa. An immunohistologic and ultrastructural study of 18 biphasic tumors and comparison with seven monophasic spindle-cell tumors. Am J Surg Pathol 1986;10:741-43.
  11. Alternative epithelial markers in sarcomatoid carcinomas of the head and neck, lung, and bladder—p63, MOC-31, and TTF-1. Mod Pathol 2005;18: 1471-81.
  12. Diagnostic surgical pathology of the head and neck. Saunders: Philadelphia 2009;78-79.
  13. Sarcomatoid carcinoma of the head and neck: Molecular evidence for evolution and progression from conventional squamous cell carcinomas. Am J Surg Pathol 2003;27:1216-20.
  14. Spindle cell carcinoma: Ultrastructural evidence of squamous origin and collagen production by the tumor cells. Cancer 1976;37:2275-82.
  15. Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harbouring Harvey ras gene alterations. Cancer Res 1992;52:680-87.
  16. Spindle cell variant of squamous carcinoma—A light and electron microscopic study of 13 cases. Cancer 1970;26(6):1311-20.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.